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Be sure to talk to your doctor for sound advice before starting any weight loss program and understand it will take time and discipline for permanent results. If you stop taking your weight loss medication, continue with your diet and exercise program, as directed by your physician.

Before taking orlistat, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Orlistat (alli, Xenical) can be used for longer-term weight loss, including the maintenance of previously lost weight. You can also get alli at the drugstore without a prescription.

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If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

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Many stimulant-type weight loss medications like phentermine or diethylpropion are only recommended for short-term use (up to 12 weeks) due to risk of dependence and other side effects.

See also How to Use section.

If you take cyclosporine, take it at least 3 hours before or after orlistat to make sure the full dose of cyclosporine is absorbed into your bloodstream. If you take levothyroxine, take it at least 4 hours before or after orlistat.

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Changes in your bowel function often occur because of the unabsorbed fat. Fatty/oily stool, oily spotting, intestinal gas with discharge, a feeling of needing to have a bowel movement right away, increased number of bowel movements, or poor bowel control may occur. These side effects may get worse if you eat more fat than you should. If these effects last or get worse, notify your doctor promptly.

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Prescription weight loss drugs such as phentermine and topiramate (Qsymia), bupropion and naltrexone (Contrave) are used for chronic, long-term weight loss, but only if adequate results occur. In general, if a 3% to 4% weight loss has not been achieved after 12 to 16 weeks, long-term treatment is typically stopped.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.

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The latest prescription drugs, like Zepbound, Wegovy and Saxenda are approved for chronic (long-term) weight loss and come as subcutaneous (under the skin) injections. Up to a 20% weight loss has been seen with these newer treatments. But digestive tract symptoms commonly occur and may lead some people to stop treatment.

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In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Nausea and vomiting, diarrhea, constipation, headache, dizziness, injection site reactions, heartburn, fatigue, dizziness, stomach-area pain, fever, and stomach infection (gastroenteritis).

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