Malignant endometrial polyps: Report of two cases and review of literature with emphasize on recent advances

The study was approved by the Research Ethics Committee of the Hospital do Servidor Público Estadual “Francisco Morato de Oliveira” and registered under number 037/08.

No. In fact, it is estimated that only 5 percent become cancerous. This is the reason why endometrial polyps should be surgically removed as soon as they are detected.

24. Costa-Paiva L, Godoy CE, Jr, Antunes A, Jr, Caseiro JD, Arthuso M, Pinto-Neto AM. Risk of malignancy in endometrial polyps in premenopausal and postmenopausal women according to clinicopathologic characteristics. Menopause. 2011; 18 (12):1278–1282. [PubMed] [Google Scholar]

Endometrial Polyps | Radiology Key

Premalignant and malignant lesions in endometrial polyps in patients undergoing hysteroscopic polypectomy

Uterine Polyps

This is a report of histologic and immunhistochemical features of two cases of endometrial polyps in postmenopausal women revealed serous and clear cell carcinoma with review of literature, emphasizing on precursor lesions and recent advances on the molecular pathways.

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What types of polyps are there?

Corresponding author: Marco Antonio Lenci – Service of Gynecology and Obstetrics, Hospital do Servidor Público Estadual de São Paulo, Rua Pedro de Toledo, 1,800, 4th floor – Vila Clementino – Zip code: 04039-901 – São Paulo, SP, Brazil – Phone: (55 11) 3849-7099 – E-mail: rb.moc.lou@icnelam

In summary, this paper reported two cases of type II endometrial carcinoma in dualistic model of endometrial carcinogenesis in association with presumed precursor lesion in one case developed on endometrial polyp. It should be emphasized that endometrial polyps especially the symptomatic and larger one and the polyps developed in postmenopausal patients have tendency to show malignant change. Therefore, careful histologic examination of these lesions to find premalignant and malignant lesions should be emphasized.

The calculation of the agreement was made using a 2×2 table and the application of Bayes’ theorem. The calculation results showed a sensitivity of 38.5%, specificity of 96.4%, a positive predictive value of 21.7%, and a negative predictive value of 98.4%. The agreement was 94.9% and the disagreement was 5.1%. The value of Cohen’s kappa coefficient was k=0.2535, which was less than the value k=0.4000, thus revealing insufficient agreement.

Malignant endometrial polyps: Report of two cases and review of literature with emphasize on recent advances

Most are noncancerous. They pop up inside your nasal passages or sinuses when the lining is inflamed and swollen for a long time. They can weaken your sense of taste or smell, and cause a runny nose, headache, and snoring. Often they grow big enough to cause infections or make it hard to breathe.

Most endometrial polyps have no symptoms and the woman is not aware of them until she gets a diagnosis after a routine gynecological exam.

There is no reason why. Most polyps that appear in the uterus are benign, but there are about 5% that become malignant. The important thing is to monitor this growth in the uterus and, if it causes symptoms such as abnormal bleeding, it should be removed.

Malignant uterine polyps: types, symptoms and treatments

Endometrial polyp | Radiology Reference Article | Radiopaedia.org

Polyps are removed using a surgical procedure called hysteroscopic polypectomy. It involves the insertion of a hysteroscope vaginally in order to detect and remove the polyp by cutting or shaving it off.

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As to management, some authors advocate the systematic removal of all symptomatic polyps. (2,5,7,13,15–18) Therefore, the best option is an operative hysteroscopy, for it is a quick procedure with few risks, presenting excellent cost-effectiveness. (19)

After the development of smaller caliber and more delicate instruments, which made possible the concept of “see and treat”, the management of this condition started to become less controversial. Thus, polyps of up to 2.0cm can be removed at the time of the diagnosis, in an outpatient clinic setting, needing no hospitalization and anesthesia. (33)

Andreas Ciscato, Somaye Y Zare, Oluwole Fadare. The significance of recurrence in endometrial polyps: a clinicopathologic analysis. Hum Pathol. 2020 Jun;100:38-44. doi: 10.1016/j.humpath.2020.03.005. Epub 2020 Apr 22 (Ver)

What You Need to Know About Polyps

Uterine Polyps | Endometrial Polyps

There are several resources for the diagnosis of endometrial polyps, and transvaginal ultrasonography, with or without Doppler flowmetry, is considered the gold standard among noninvasive diagnostic methods. Among the methods considered invasive, outpatient hysteroscopy is the best method for diagnosing endometrial polyps, with 95.6% agreement between the image and the pathological diagnosis. (14) Using hysteroscopy, it is possible to quantify the polyps, analyze the vascularization of their surface, their shape, location, size and width of the implantation base, and it also makes feasible a directed or guided biopsy. (2,9,15)

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Conclusion:

Yes. In this case, they are called precancerous polyps. All organic endometrial polyps can eventually turn into cancer if not removed on time.

25. Nogueira AA. Pólipos endometriais. Rev Bras Ginecol Obstet. 2005; 27 (5):289–292. [Google Scholar]

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